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Figure 6
(a) Schematic representation of the cofactor and (b) a stereoview of the putative binding site for AcCo of SsATA; AcCoA is overlaid from the NATA complex (PDB entry 4kvm ) in stick representation. The cavity-surrounding secondary-structure elements of SsAT are shown as a cartoon representation. Residues which are most likely to coordinate AcCoA are highlighted as sticks and are labelled accordingly. The corresponding residues in NATA (shown in grey) overlap well with the residues of SsAT, supporting the proposed binding mode. The pyrophosphate-coordinating residues correspond to the conserved P-loop, a signature motif of acetyltransferases.

Journal logoBIOLOGICAL
CRYSTALLOGRAPHY
ISSN: 1399-0047
Volume 70| Part 1| December 2014| Pages 186-195
doi:10.1107/S1399004713029155
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