Figure 1
Composition of the microenvironment of KCX sites and LYS sites (buried and surface lysine residues). Frequency of amino acids, metal ions and water molecules found within 5 Å of the side chain of Kcx (black bars), buried Lys (magenta bars) and surface Lys (gray bars) residues (see also Supplementary Tables S2 and S3). The amino acids found in the microenvironments are grouped according to their main physicochemical properties, i.e. positively charged (Arg, Lys and His), negatively charged (Asp and Glu), aromatic (Trp, Phe and Tyr) and hydrophobic (Ile, Leu, Val and Met) residues. The x axis represents the number of amino acids around the KCX and LYS sites, while the y axis represents the frequencies of each count. |