Figure 6
Mapping of conserved exposed residues onto the TRAF4 TRAF domain with a coiled-coil domain. (a) Structure-based sequence alignment. The surface residues involved in interaction with binding receptors in TRAF2, TRAF3 and TRAF6 are shown in blue. Conserved exposed residues in TRAF4 are shown in red. The three interaction regions in the TRAF domain are indicated by a black dotted square (first region), a red dotted square (second region) and a blue dotted circle (third region). (b) Conserved exposed residues that might be involved in receptor interaction are mapped onto the TRAF4 TRAF domain. Red residues are deduced from structural information on the complex between TRAF2 or TRAF3 and their binding receptors. Blue residues are deduced from structural information on the complex between TRAF6 and its binding receptors. |