Figure 5
(a) The GSH-binding site in PfGrx1. Bound MOPS (pink) and water molecules (orange spheres) are shown. Atom interactions are shown as dashed lines. (b) Superposition of the active sites of PfGrx1 (green) and glutathionylated HsGrx2 (blue). (c) A water molecule that is structurally conserved in Grxs is shown. An additional water-mediated salt bride in PfGrx1 is also shown. |