Figure 2
Conformation of the active-state kinase domain (KD) in MPK38 (T167E). The UBA domain is shown in yellow, the UBA linker in green, the activation loop in red and the αC helix in blue. (a) Overview of the MPK38 (T167E) structure. (b) Close-up view of the αC-in conformation. The ion pair between Lys40 and Glu57 is marked as a red dashed line. (c) Close-up view of the DFG-in conformation. |