Figure 4
Activation of MPK38 by phosphorylation of the activation loop. (a) The activation loop of MARK1 (white) and MPK38 (T167E) (blue) are shown as boxed regions. (b) The interlobar cleft in MARK1 has a more open conformation compared with that of MPK38 (T167E). MARK1 (white) and MPK38 (T167E) (blue) are superposed and the N-lobes and C-lobes of their KDs are highlighted by ellipses. The N-lobe of MARK1 is shown in the grey ellipse, the N-lobe of MPK38 (T167E) is shown in the blue ellipse and the C-lobes of both proteins are shown in the green ellipse. |