Figure 5
Comparison of the activation of MPK38 by ExS and the inhibition of Snf1 (from S. pombe) by AID. (a) Structural comparison of MPK38 (T167E) (blue) with Snf1 (yellow) is shown via an overall view (left) and a close-up view (right) of the boxed region. (b) Each protein in the boxed region of (a) is displayed separately. The structures show the van der Waals contacts at the interface of the KD–UBA linker region of MPK38 and those at the KD–AID interface of Snf1. (c) A close-up view of the region around the αC helix in both proteins shows that the interactions observed in (b) force αC to rotate inwards (MPK38) or outwards (Snf1). |