Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor–ligand complex

Andersen, J.L.; Schrøder, T.J.; Christensen, S.; Strandbygård, D.; Pallesen, L.T.; García-Alai, M.M.; Lindberg, S.; Langgård, M.; Eskildsen, J.C.; David, L.; Tagmose, L.; Simonsen, K.B.; Maltas, P.J.; Rønn, L.C.B.; de Jong, I.E.M.; Malik, I.J.; Egebjerg, J.; Karlsson, J.-J.; Uppalanchi, S.; Sakumudi, D.R.; Eradi, P.; Watson, S.P.; Thirup, S.

doi:10.1107/S1399004713030149

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 4
Overview of AF40431 binding to sortilin. The ten blades of the β-propeller and the 10CC domain are represented as grey and green cartoons, respectively. Neurotensin was superimposed from PDB entry 3f6k (Quistgaard et al., 2009

) and is depicted as a purple ball-and-stick representation; AF40431 is depicted as orange sticks and spheres.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 70| Part 2| January 2014| Pages 451-460

doi:10.1107/S1399004713030149

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