 | Acta Crystallographica Section D Acta Crystallographica Section D BIOLOGICAL CRYSTALLOGRAPHY |
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![[Figure 4]](kw5080fig4mag.jpg)
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Figure 4
1H–15N two-dimensional NMR correlation spectrum of U-2H,15N-enriched wild-type FKBP12.6. Residues exhibiting resolved resonances for the minor slow-exchange conformation are indicated in red. Resonances were not observed in this spectrum for Ala84 and for Gly89 in the major slow-exchange state presumably owing to severe line-broadening arising from both rapid amide hydrogen exchange (Hernández et al., 2009  ) and conformational exchange dynamics in the 80s loop (Mustafi et al., 2013) as observed in the homologous FKBP12. The Gly89 resonance for the minor exchange state is observable at an approximately twofold lower contour level. The assessment of resonance doubling for Val80 is impeded by overlap with a side-chain amide resonance. Folded side-chain resonances are indicated with `x'. |
![[Figure 4]](kw5080fig4.jpg)
| BIOLOGICAL CRYSTALLOGRAPHY |
ISSN: 1399-0047
