Role of κ→λ light-chain constant-domain switch in the structure and functionality of A17 reactibody

Ponomarenko, N.; Chatziefthimiou, S.D.; Kurkova, I.; Mokrushina, Yu.; Mokrushina, Y.; Stepanova, A.; Smirnov, I.; Avakyan, M.; Bobik, T.; Mamedov, A.; Mitkevich, V.; Belogurov, A.; Fedorova, O.S.; Dubina, M.; Golovin, A.; Lamzin, V.; Friboulet, A.; Makarov, A.A.; Wilmanns, M.; Gabibov, A.

doi:10.1107/S1399004713032446

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 6
Structural superposition of the A17κ (blue) and A17λ (magenta) light chains on the V_L domain. The Gly-L110 insertion in A17λ accounts for the change in the V_L–C_L orientation compared with that in A17κ.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 70| Part 3| February 2014| Pages 708-719

doi:10.1107/S1399004713032446

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