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Figure 3
Active site and enzyme inhibition. (a) Schematic of the active-site region in SGSH. A Ca2+ ion is coordinated by side-chain P atoms from Asp31, Asp32, Asp273, Asn274 and the phosphorylated FGly70, which is in turn stabilized by interactions with the side chains of residues Arg74, Lys123, His125, His181, Asp273 and Arg282. (b) Inhibition of SGSH acitivity by phosphate and sulfate. The IC50 of phosphate was determined to be 1 mM; the IC50 of sulfate was 5 mM.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 70| Part 5| May 2014| Pages 1321-1335
https://doi.org/10.1107/S1399004714002739
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