Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase

Dempster, S.; Harper, S.; Moses, J.E.; Dreveny, I.

doi:10.1107/S1399004714005422

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 4
Superposition of the human LDH-A apo form (grey) and NADH binary complex (purple) reported here with the ternary complex bound to NADH and the competitive inhibitor oxamate (two different monomers shown in blue and light blue, respectively; PDB entry 1i10; Read et al., 2001

), highlighting the conformational changes upon cofactor and substrate binding, with key residues shown in stick representation.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 70| Part 5| May 2014| Pages 1484-1490

https://doi.org/10.1107/S1399004714005422

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