Figure 3
The helicase core of hPrp28ΔN has an open overall conformation as the two RecA domains are displaced with respect to the active conformation represented by Vasa (purple). Superposition of hPrp28ΔN with (a) Vasa in its active closed conformation and other DEAD-box proteins exhibiting an open conformation: (b) Prp5, (c) UAP56, (d) Dhh1p, (e) eIF4A and (f) eIF4AIII. (g) Superposition of (a)–(f). |