Figure 6
Comparison of the mC5a/mC5a-desArg structures with hC5a. (a) Superimposition of the mC5a (blue) and mC5a-desArg (beige) structures. (b) Superimposition of mC5a (blue) with the structure of hC5a from human C5 (green; Fredslund et al., 2008) or from the NMR model (orange; Zhang et al., 1997). (c, d) Stabilizing interactions between helices H1 and H4 in the four-helix bundle models of mC5a (blue) and hC5a (green). The residues involved in hydrogen bonds, salt bridges and hydrophobic interactions at the H1–H4 interface are represented as sticks in both structures. |