Figure 1
Crystal structures of PfSHMT and hSHMT. (a) Two homodimers of the PfSHMT-F292E structure at 3 Å resolution, showing two protomers in dimer 1 and dimer 2. (b) PfSHMT dimer interface in crystal packing. (c) The three domains of the PfSHMT protomer: N (residues 1–34), large PLP binding (residues 35–290) and C domains (residues 291–442); PLP is shown in yellow stick represenation. (d) The native tetrameric form of hSHMT shown in brown and yellow with the flap motif (residues 274–285) in black. |