Structural and biochemical analyses of alanine racemase from the multidrug-resistant Clostridium difficile strain 630

Asojo, O.A.; Nelson, S.K.; Mootien, S.; Lee, Y.; Rezende, W.C.; Hyman, D.A.; Matsumoto, M.M.; Reiling, S.; Kelleher, A.; Ledizet, M.; Koski, R.A.; Anthony, K.G.

doi:10.1107/S1399004714009419

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 7
Comparison of C. difficile and E. coli Alr. (a) Superposed ribbon diagram of CdAlr_K271T (gray) with EcAlr (cyan). The larger hinge angle of EcAlr is obvious from the displacement of the corresponding loops in the C-terminal domain, indicated by arrows. The N-terminal residue (Lys3) and C-terminal (Lys385) residue of the CdAlr_K271T structure are labeled. Also labeled are the N-terminal (Met1) and C-terminal (Asp359) residues of the EcAlr structure. (b) A stereoview of the superposed active sites of CdAlr_K271T (gray) and EcAlr (green). (c) A stereoview of the superposed residues in the active site of CdAlr_cycloserine (gray) and EcAlr in complex with cycloserine (green).

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 70| Part 7| July 2014| Pages 1922-1933

https://doi.org/10.1107/S1399004714009419

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