Figure 2
Sequence alignment of ICAM-5, ICAM-1 and ICAM-2. Structure-based sequence alignment is shown for the D1–D4 fragment and a sequence alignment is shown for D5. The ICAM-5 D1–D2 and D3–D4 modules of the monoclinic P21 crystal structure were structurally aligned with the homologous modules of ICAM-1 and ICAM-2. The first residue of each domain is labelled and β-strands are marked above the sequences. Cysteines are highlighted in green and glycosylated Asn in yellow; basic residues in D1–D2 are in cyan and acidic residues in D3–D5 are in red. |