Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions

Recacha, R.; Jiménez, D.; Tian, L.; Barredo, R.; Gahmberg, C.G.; Casasnovas, J.M.

doi:10.1107/S1399004714009468

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 5
Electrostatic-based intermolecular interactions between N-terminal and C-terminal modules of IC5-4D in the crystals. Ribbon diagram of interacting domains colored as in Fig.1

(see also Supplementary Fig. S3). β-strands and interacting charged residues, shown in Supplementary Table S1, are labeled. Salt bridges and hydrogen bonds are shown as dashed lines. (a) Contact in the P4₃22 crystal structure (interface A). (b) Contact in the P2₁ crystals (interface B), also observed in the R3 crystal structure. (c) Contact in the P2₁ crystal structure (interface C). The glycan linked to Asn282 is as spheres with carbon in yellow, nitrogen in blue and oxygen in red.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 70| Part 7| July 2014| Pages 1934-1943

https://doi.org/10.1107/S1399004714009468

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