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![[Figure 1]](cb5053fig1mag.jpg)
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Figure 1
Peptidoglycan is an essential polymeric component of Gram-negative and Gram-positive bacteria. (a) O-Acetylation is a PGN modification found in many Gram-negative and Gram-positive bacteria carried out by the concomitant action of the enzymes PatA and PatB. This modification is resistant to the action of lysozyme and lytic transglycosylases (LTs). After removal of this modification by Ape1 the bacterium is sensitive to the action of lysosyme and LTs. (b) Schematic of the reaction catalyzed by Ape1. Ape1 removes the acetyl modification at the C-6 hydroxyl moiety of the MurNAc residue. |
![[Figure 1]](cb5053fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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