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Figure 3
Active-site conservation in the SGNH hydrolase superfamily. (a) Surface model of Ape1 displaying the active groove for acetate. According to the active-site arrangement, this groove is absolutely conserved in all members of the SGNH hydrolase superfamily. (b) The structure of a putative arylesterase from Agrobacterium tumefaciens (PDB entry 3dci; Midwest Center for Structural Genomics, unpublished work). (c) Platelet-activating factor with bound acetate in the active-site groove (PDB entry 1wab; Ho et al., 1997 ![]() ![]() |
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