Figure 2
Inhibition of the binding of human 125I-TyrA14 insulin to IR by human insulin and insulin analogues. (a) Inhibition of the binding of human 125I-TyrA14 insulin to rat adipose plasma membranes containing both IR-A and IR-B isoforms of rat IR by human insulin (circles) and [GlyB26]-insulin (squares). (b–e) Inhibition of the binding of human 125I-TyrA14 insulin to the IR-A isoform of human IR in membranes of human IM-9 lymphocytes by (b) human insulin, (c) [AsnB26]-insulin, (d) [AspB26]-insulin and (e) [GlnB26]-insulin. (f) Inhibition of the binding of human 125I-TyrA14 insulin to the IR-B isoform of human IR in membranes of mouse embryonic fibroblasts by human insulin (circles) and [AsnB26]-insulin (squares). |