Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmias

Borko, Ľ.; Bauerová-Hlinková, V.; Hostinová, E.; Gašperík, J.; Beck, K.; Lai, F.A.; Zahradníková, A.; Ševčík, J.

doi:10.1107/S1399004714020343

Figure 4
Electrostatic potential distribution of hRyR2^1–606 surface. (a) A view of the four monomers of hRyR2^1–606 that form the central rim of the RyR, with one of the monomers showing the potential distribution. Domains A, B and C are shown in blue, green and red, respectively. (b) A view of the potential distribution (blue, positive; red, negative) of the surface of domain A that interacts with domain B of the neighbouring hRyR2^1–606 monomer (green ribbon). (c) A view of the potential distribution of the surface of domain B that interacts with domain A of the neighbouring hRyR2^1–606 monomer (blue ribbon). (d–f) Electrostatic potential distribution at the interfaces A/B (d), B/C (e) and A/C (f) of hRyR2^1–606. One side of the interface is shown as a electrostatic potential surface, while the complementary side is shown as a ribbon (blue, green and red for domains A, B and C, respectively). The two views were created by a 180° rotation around the vertical axis. Residues with a substantial electrostatic potential are indicated. Most of the interactions between domains A/C and B/C involve residues from the central helix (Table 3

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 70| Part 11| November 2014| Pages 2897-2912

https://doi.org/10.1107/S1399004714020343

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