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![[Figure 2]](rr5081fig2mag.jpg)
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Figure 2
Sequence alignments of Psy-Lig with other ATP-dependent DNA ligases. Fully conserved residues are shaded red; partially or homologously conserved residues are shown in red text. Structural features discussed in the text and the conserved motifs of the nucleotidyltransferase enzymes are indicated in boxes, with numbering corresponding to the conventions given in Shuman & Lima (2004  ). α-Helices are indicated by curl symbols and β-strands by arrows. Filled boxes above the sequences give the numbering of the secondary-structural elements of Psy-Lig as referred to in the text, and correspond to the colours and numbering used in the ribbon diagram (inset). (a) Structure-based alignment between Psy-Lig and ChlV-Lig constructed using PDBeFold. (b) Sequence-based alignment of Psy-Lig with biochemically characterized ligases from H. influenzae (Hin-Lig), N. meningitidis (Nme-Lig) and A. salmonicida (Vib-Lig). |
![[Figure 2]](rr5081fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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