Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control

Chitnumsub, P.; Jaruwat, A.; Riangrungroj, P.; Ittarat, W.; Noytanom, K.; Oonanant, W.; Vanichthanankul, J.; Chuankhayan, P.; Maenpuen, S.; Chen, C.-J.; Chaiyen, P.; Yuthavong, Y.; Leartsakulpanich, U.

doi:10.1107/S1399004714023128

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

IUCr IT WDC

home archive editors for authors for readers submit subscribe open access

view article

Figure 1
Crystal structure of PvSHMT. (a) The dimer interface of two PLP and amino-acid substrate pockets with interactions contributed by Leu99, Arg243, His274 and Lys277 from protomers A (coloured cyan and pink) and B (coloured green and magenta). (b, c) Conformation of Arg243 (b) in the PLP–Lys237 Schiff-base complex and (c) in the PLP–L-Ser Schiff-base complex (PLS). (d) Superposition of the 4pff (violet) and 4pfn (cyan) dimers shows the rotation of the PLP ring by 18° from the PLP–Lys237 Schiff base (orange) to the PLP–L-Ser Schiff base (yellow).

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 70| Part 12| November 2014| Pages 3177-3186

doi:10.1107/S1399004714023128

Follow Acta Cryst. D

Search term		doi		Advanced search
Author		volume	page