Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control

Chitnumsub, P.; Jaruwat, A.; Riangrungroj, P.; Ittarat, W.; Noytanom, K.; Oonanant, W.; Vanichthanankul, J.; Chuankhayan, P.; Maenpuen, S.; Chen, C.-J.; Chaiyen, P.; Yuthavong, Y.; Leartsakulpanich, U.

doi:10.1107/S1399004714023128

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 5
Surface electrostatic potential. (a) Dimeric PvSHMT–D-Ser–(6R)-5FTHF, with the inset showing key residues involved in folate binding: Tyr′54, Glu′56, Lys′60, Lys′61, Tyr′63 and Tyr′64 in the YEY loop and Lys138 and Lys139 in loop-C125. (b) Dimeric ecSHMT (PDB entry 1dfo ). (c) Tetrameric rSHMT (PDB entry 1ls3 ). Each structure contains 5FTHF, but that of rSHMT contains triGlu-5FTHF.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 70| Part 12| November 2014| Pages 3177-3186

doi:10.1107/S1399004714023128

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