 | Acta Crystallographica Section D Acta Crystallographica Section D BIOLOGICAL CRYSTALLOGRAPHY |
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![[Figure 1]](mn5075fig1mag.jpg)
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Figure 1
(a) Schematic presentation of the degradation of 3-ketodecanoyl-CoA into acetyl-CoA and octanoyl-CoA by human mitochondrial 3-ketoacyl-CoA thiolase. (b) Proposed mode of binding of the thioester O atom of the fatty acyl-CoA in OAH1 or OAH2. In this mode of binding a negative charge developing on the thioester O atom is stabilized, thereby facilitating nucleophilic attack by a water molecule on the carbonyl C atom and thus favouring the hydrolysis of the thioester moiety by a water molecule. For an efficient reaction with water it is required that a catalytic base abstracts a proton from this water and donates it to CoA, the leaving group of the thioesterase reaction. |
![[Figure 1]](mn5075fig1.jpg)
| BIOLOGICAL CRYSTALLOGRAPHY |
ISSN: 1399-0047
