Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms

Kolappan, S.; Shen, D.L.; Mosi, R.; Sun, J.; McEachern, E.J.; Vocadlo, D.J.; Craig, L.

doi:10.1107/S1399004714024791

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 3
Interactions of oxalate and NADH in the ternary LDHA complex. (a, b) Solvent-excluded tunnel with oxalate and NADH bound shown in two different views. LDHA is shown in grey space-filling representation with its active-site loop coloured orange. Ligands are shown in stick representation, with oxalate C atoms coloured green, NADH C atoms yellow, N atoms blue, O atoms red and phosphates orange. (c) Interactions between oxalate and the LDHA substrate-binding site. Interacting side chains are shown in stick representation. (d) Interactions between NADH and the co-substrate-binding site.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 71| Part 2| February 2015| Pages 185-195

https://doi.org/10.1107/S1399004714024791

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