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![[Figure 1]](kw5102fig1mag.jpg)
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Figure 1
The overall structure of DacB. (a) A cartoon representation of the DacB structure. The zinc ion in the active site is shown as a grey sphere and the acetate molecule is shown as yellow sticks. (b) Superposition of DacB from S. pneumoniae TIGR4 on chain A of DacB from S. pneumoniae D39 (salmon; PDB entry 4d0y) and SpLdcB in complex with D-Ala (lemon; PDB entry 4ox5). (c) Superposition of DacB from S. pneumoniae TIGR4 on chain B of DacB from S. pneumoniae D39 (wheat; PDB entry 4d0y) and SpLdcB in complex with a product mimic (orange; PDB entry 4oxd). The rearrangements of the β5–α5 loop and N-terminus of helix α5 are highlighted as red cartoons. (d) Superposition of DacB from S. pneumoniae TIGR4 on the vancomycin-resistance bifunctional D,D-dipeptidase/D,D-carboxypeptidase VanXYC from E. gallinarum (magenta; PDB entry 4oak). The bisubstrate selectivity loop in VanXYC is coloured yellow. |
![[Figure 1]](kw5102fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
