Ligand-bound structures of 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase from Moraxella catarrhalis reveal a water channel connecting to the active site for the second step of catalysis

Dhindwal, S.; Priyadarshini, P.; Patil, D.N.; Tapas, S.; Kumar, P.; Tomar, S.; Kumar, P.

doi:10.1107/S1399004714025218

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 10
Figure showing the presence of a water molecule at the opening of the tunnel (blue spheres) near the active site. This water molecule is at a hydrogen-bond distance from Asp111 and from water molecules coordinated to the Mg²⁺ ion. The two subunits are shown as a surface view in cyan and magenta. Active-site residues are shown in stick form. The hydrogen bonds are shown as yellow dashed lines. The green sphere represents the Mg²⁺ ion and the red spheres represent water molecules.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 71| Part 2| February 2015| Pages 239-255

https://doi.org/10.1107/S1399004714025218

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