Insight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme A

Xu, X.; Li de la Sierra-Gallay, I.; Kubiak, X.; Duval, R.; Chaffotte, A.F.; Dupret, J.-M.; Haouz, A.; Rodrigues-Lima, F.

doi:10.1107/S139900471402522X

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 3
Structural comparison of different CoA-binding conformations in NATs. Overall structures (top) and electrostatic potential representations (bottom) of (RHILO)NAT1 (blue), (MYCMR)NAT1 (purple; PDB entry 2vfc), (HUMAN)NAT2 (green; PDB entry 2pfr) and (BACAN)NAT1 (grey; PDB entry 3lnb) complexed with CoA (yellow sticks) shown as ribbon diagrams. The `mammalian/eukaryotic insertion loop' of (HUMAN)NAT2 is highlighted by a red dashed line. The 15 amino acids of the insertion loop of (BACAN)NAT1 remain unresolved owing to low electron density and are indicated by a black dashed line.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 71| Part 2| February 2015| Pages 266-273

https://doi.org/10.1107/S139900471402522X

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