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Figure 3
Comparison of the huSmad2 MH2 homotrimer with the Expansion Nα-MH2 domain. (a) Structural superposition of Expansion Nα-MH2 (blue) and the huSmad2 MH2 homotrimer. Smad2 MH2 domains in the trimer are represented as cartoons coloured three shades of grey to distinguish each monomer in the homotrimeric structure. The structures are superimposed using the β-sandwich (r.m.s.d. of 0.636 Å on 43 Cα atoms). All elements of secondary structure of Expansion and of one monomer of the human Smad2 trimer overlap, but the Nα helix of Expansion is superimposed on a loop of an adjacent MH2 domain of huSmad2. The superimposed Nα helix and the H2 region are marked with rectangles (gold and green, respectively). Detailed views of these regions are shown in (b) and (c).

Journal logoSTRUCTURAL
ISSN: 2059-7983
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