 | Acta Crystallographica Section D Acta Crystallographica Section D BIOLOGICAL CRYSTALLOGRAPHY |
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![[Figure 3]](dw5130fig3mag.jpg)
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Figure 3
Uhgb_MP homohexameric structure. (a) Uhgb_MP is a hexameric structure formed by a trimer of dimers. Individual monomers are shown in a single colour and are labelled A, B, C, A′, B′ and C′ for clarity. Each pair of dimers is coloured in pale/dark blue, green and red. (b) Close-up of the catalytic tunnel of a single Uhgb_MP protomer in the hexameric structure. The quaternary-structure assembly imposes structural constraints on active-site accessibility. The inorganic phosphate, the mannose and the N-acetylglucosamine molecules present in the catalytic site of protomer A are shown as sticks deeply buried in the catalytic site, which is accessible by a tunnel whose sides are formed by different protomers. The extremity of the tunnel is located at the centre of the plane formed by four Uhgb_MP molecules, in this case A, A′, B and B′. |
![[Figure 3]](dw5130fig3.jpg)
| BIOLOGICAL CRYSTALLOGRAPHY |
ISSN: 1399-0047
