 | Acta Crystallographica Section D Acta Crystallographica Section D BIOLOGICAL CRYSTALLOGRAPHY |
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![[Figure 1]](dw5133fig1mag.jpg)
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Figure 1
Degradation of DTDP. The disulfide 3,3′-dithiodipropionic acid (DTDP) is cleaved into two molecules of 3-mercaptopropionic acid (3MP) by an NADH-dependent disulfide reductase (Wübbeler et al., 2010  ). After oxygenation of 3MP to 3-sulfinopropionic acid (3SP) by a dioxygenase (Mdo; Bruland et al., 2009), a succinate-CoA ligase (SucCD; Schürmann et al., 2011) catalyzes the activation to 3SP-CoA. Subsequently, 3SP-CoA desulfinase (Acd) catalyzes the hydrolytic cleavage, yielding propionyl-CoA and sulfite. Propionyl-CoA finally enters the central metabolism via the methyl citric acid cycle, while sulfite is most probably oxidized to sulfate by sulfite oxidases. |
![[Figure 1]](dw5133fig1.jpg)
| BIOLOGICAL CRYSTALLOGRAPHY |
ISSN: 1399-0047
