Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8

Wang, C.; Zhang, Q.; Hang, T.; Tao, Y.; Ma, X.; Wu, M.; Zhang, X.; Zang, J.

doi:10.1107/S1399004715012948

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 3
Specific recognition of Rpl8 by NO66. (a) A surface representation of the active site of NO66 is shown. Positively charged, negatively charged and neutral areas are shown in blue, red and white, respectively. The Rpl8^204–224 peptide adopts a U-shaped conformation in the active site of NO66. (b) A detailed view of the interaction network of NO66 with Rpl8^204–224 and NOG. Rpl8^204–224 and the amino-acid residues of NO66 interacting with Rpl8^204–224 are shown as stick models. Ni²⁺ and water molecules are shown as spheres. NO66, Rpl8^204–224, NOG, Ni²⁺ and water molecules are coloured grey, yellow, green, magenta and red, respectively. (c) His216 is the hydroxylation site in Rpl8 catalyzed by NO66. The distances between the C^β atoms of His216 and His218 and the Ni²⁺ ion in the active site are shown.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 71| Part 9| August 2015| Pages 1955-1964

doi:10.1107/S1399004715012948

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