Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8

Wang, C.; Zhang, Q.; Hang, T.; Tao, Y.; Ma, X.; Wu, M.; Zhang, X.; Zang, J.

doi:10.1107/S1399004715012948

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 4
NO66 recognizes Rpl8 through a consensus motif. (a) A sequence alignment of the fragment in Rpl8 which is recognized by NO66 is shown. The accession numbers of the protein sequences are Homo sapiens, NP_150644 (human); Macaca mulatta, NP_001253030 (rhesus macaque); Bos taurus, NP_001029797 (cattle); Mus musculus, NP_036183 (mouse); Rattus norvegicus, NP_001030088 (rat); Danio rerio, NP_957007 (fish); Drosophila simulans, NP_728756 (fly). The residues that are critical for the binding of Rpl8 to NO66 are highlighted in red. (b) Pull-down of NO66^176–C by wild-type Rpl8^193–C and mutants of Rpl8^193–C fused to GST are shown.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 71| Part 9| August 2015| Pages 1955-1964

doi:10.1107/S1399004715012948

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