Structural insights into the interaction of human IgG1 with FcγRI: no direct role of glycans in binding

Oganesyan, V.; Mazor, Y.; Yang, C.; Cook, K.E.; Woods, R.M.; Ferguson, A.; Bowen, M.A.; Martin, T.; Zhu, J.; Wu, H.; Dall'Acqua, W.F.

doi:10.1107/S1399004715018015

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 1
General view of the complex formed between human IgG1 Fc and the ECD of human FcγRI. (a) The Fc–FcγRI (salmon/green) complex is shown as ribbons and carbohydrates as sticks. FcγRI D2 appears to be the lone structural contributor to the interface with Fc. (b) Surface representation of the Fc–FcγRI complex, in which FcγRI (green) has been moved 20 Å away from Fc (orange) to show the shape complementarity. This and other figures were prepared using PyMOL (Schrödinger).

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 71| Part 11| October 2015| Pages 2354-2361

doi:10.1107/S1399004715018015

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