Structural insights into the interaction of human IgG1 with FcγRI: no direct role of glycans in binding

Oganesyan, V.; Mazor, Y.; Yang, C.; Cook, K.E.; Woods, R.M.; Ferguson, A.; Bowen, M.A.; Martin, T.; Zhu, J.; Wu, H.; Dall'Acqua, W.F.

doi:10.1107/S1399004715018015

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 3
(a) Representation of the intermolecular contacts between Fc (E chain, salmon; significance of 0.963) and FcγRI D2 (green). (b) FcγRI creates a pocket (`lock') to fit Leu235 in the Fc E chain (`key'; salmon). (c) Representation of the intermolecular contacts between Fc (J chain, salmon; significance of 0.348) and FcγRI D2 (green). Fc residues were numbered according to the EU numbering convention (Kabat et al., 1991

). Dotted lines represent hydrogen bonds (distances are given in Å). None of the interfaces involved carbohydrates.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 71| Part 11| October 2015| Pages 2354-2361

doi:10.1107/S1399004715018015

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