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Figure 5
Rotation of the His39 side chain in response to small-molecule binding. (a) In the presence of glycerol (magenta) or ethylene glycol (green), the His39 side chain is rotated relative to its position in the crystal structures of either WT PaDsbA1 (blue) or E82I PaDsbA1 (orange) in the absence of a small molecule at the active site. (b) Glycerol (GOL) and ethylene glycol (EDO) bind at the same site in E82I PaDsbA1 and make equivalent hydrogen-bond contacts to His39.

Journal logoBIOLOGICAL
CRYSTALLOGRAPHY
ISSN: 1399-0047
Volume 71| Part 12| November 2015| Pages 2386-2395
doi:10.1107/S1399004715018519
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