Figure 1
Sequence analysis of MERS-CoV N protein. (a) Modular organization of the coronavirus N protein. The domain boundaries correspond to the MERS-CoV N protein numbering. IDR, intrinsically disordered region; NTD, N-terminal domain; CTD, C-terminal domain. (b) Sequence alignment of the N-terminal region of several N proteins for which the structure of the NTD has been documented. The sequences are named as follows: virus acronym_PDB code. The depicted secondary structure was retrieved from the MERS-CoV NTD+ structure described in this study. The alignment was obtained using T-Coffee (Notredame et al., 2000) and ESPript 3.0 (Robert & Gouet, 2014). |