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![[Figure 2]](ba5238fig2mag.jpg)
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Figure 2
(a) Surface representation of the βhingeHis6.AP2 `extended core' complex, coloured as in Fig. 1 ![[link]](../../../../../../logos/arrows/d_arr.gif) but in paler shades for clarity. Shown in yellow is the positive mFo − DFc difference density in the `bowl' after restrained refinement of the locked AP2 core structure lacking the hinge fragment (PDB entry 2vgl
) against the βhingeHis6.AP2 data. (b) Cutaway of the same view of the complex as in (a), showing the buried difference density deep in the `bowl'. (c–e) mFo − DFc maps (contoured at ±3σ, positive density in green and negative density in red) after restrained refinement of the locked AP2 core structure (PDB entry 2vgl
) against the βhingeHis6.AP2 data (c) and against data obtained from constructs with β2 subunits truncated at Leu636 (d) and Gln619 (e). The appropriate β2 subunit is shown schematically beneath each map. (f) C-terminal sequences of the β2 constructs depicted in (c), (d) and (e), starting at the first disordered residue of the β2 hinge region and with the clathrin-box motif underlined. |
![[Figure 2]](ba5238fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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