Figure 1
Cartoon representations of the COP9 signalosome complex (centre) and its constituent proteins: the two MPN domain-containing subunits (CSN5 and CSN6; above) and six PCI domain-containing proteins (CSN1–CSN4, CSN7 and CSN8; below). The winged-helix subdomain of each of PCI protein is coloured grey and the Zn2+ ion in the active site of CSN5 is labelled. Major loops that were unmodelled because of disorder are shown as dashed lines. |