Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site

Chen, H.; Tucker, J.; Wang, X.; Gavine, P.R.; Phillips, C.; Augustin, M.A.; Schreiner, P.; Steinbacher, S.; Preston, M.; Ogg, D.

doi:10.1107/S2059798316004502

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 7
Kinase-panel selectivity for ERK5 inhibitors 2, 3 and 5. The violet lines indicate kinases for which the percentage inhibition is above 80%, the orange lines those where it is between 40 and 80%, and the light blue lines those where it is less than 40%.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 72| Part 5| May 2016| Pages 682-693

doi:10.1107/S2059798316004502

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