Figure 1
The four stereoisomers of hydroxycitrate. The compound produced by G. cambogia is (−)-hydroxycitrate or (2S,3S)-2-hydroxycitrate. The nomenclature defined by Sullivan et al. (1977) gives the pro-R branch lower numbering than the pro-S branch (Sullivan et al., 1977) and this stereoisomer was renamed (4S)-OHcit-(pncit) (Stallings et al., 1979). In this work, it is referred to as 4S-hydroxycitrate, while (−)-allohydroxycitrate or (2R,3S)-2-hydroxycitrate is referred to as 4R-hydroxycitrate. |