Figure 6
Structural elements contributing to cyclization specificity in MdCHS2, MdBIS3 and HaBPS. (a) The aldol-switch residues of stilbene synthase (PDB entry 1u0u) superposed onto MdCHS2 (blue). Residues are displayed as sticks. Atoms are color-coded according to element: oxygen, red; nitrogen, blue; sulfur, yellow. Water is shown as a cyan sphere. Hydrogen bonds are shown as dashed lines with associated distances in Å. (b) Active-site regions of MdBIS3 and HaBPS, homologous to the stilbene aldol switch, are overlayed and displayed as sticks. |