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![[Figure 3]](kw5140fig3mag.jpg)
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Figure 3
Demonstration of the two topology types observed in the C-terminal region of folate-binding modules. (a) Superposition of the Fol modules from T. thermophilus and T. thermotoga MS. The Fol module of T. thermophilus MS is illustrated in cartoon mode and shown in green, except for the C-terminal four helices, which are shown in red. T. thermotoga MS (PDB entry 1q8j) is shown in cyan, except for the last helix (α8F), which is colored blue. (b) Structural alignment of the Fol modules of MS. The Fol modules of T. thermophilus MS [colored green and red as in (a)], H. sapiens (pale blue; PDB entry 4ccz) and B. thetaiotaomicron (yellow; PDB entry 3k13) are drawn in cartoon mode. (c) Structural alignment of pterin-binding superfamily members. The Fol module of T. thermotoga MS is shown in cyan and blue as in (a). The folate-binding domains of MeTr from M. thermoacetica (PDB entry 2e7f) and MT2DH from D. hafniense (PDB entry 4o1e) are displayed in pink and gray, respectively, and the last nonconserved helices are transparent. A monomer of DHPS from S. aureus (PDB entry 1ad4) is colored orange. |
![[Figure 3]](kw5140fig3.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
