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![[Figure 1]](ag5016fig1mag.jpg)
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Figure 1
Structure of the D25N HIV-1 protease–CA/p2 complex. Protease residues from chain A are shown in white and those from chain B in gray; the substrate CA/p2 is shown in ball-and-stick representation (PDB entry 1f7a; Prabu-Jeyabalan et al., 2000  ). (a) The substrate CA/p2 binds in the active site of the protease (white and gray) in an extended conformation between the two flaps and the core domain. (b) The substrate side chains are numbered relative to the scissile bond. |
![[Figure 1]](ag5016fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
