A substrate selected by phage display exhibits enhanced side-chain hydrogen bonding to HIV-1 protease

Windsor, I.W.; Raines, R.T.

doi:10.1107/S2059798318006691

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 4
Role of Asp30. (a) Network of hydrogen bonds formed by Glu6 (P2′) and Ser8 (P4′) of SGIFLETS. Protease residues from chain A are shown in white and SGIFLETS in orientation B is shown in black. (b) Analogous hydrogen bonds formed by Ser2 (P4) and Asn4 (P2) of the MA/CA substrate (PDB entry 1kj4), although these residues interact with each other and only Ser2 interacts with Asp30.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 74| Part 7| July 2018| Pages 690-694

https://doi.org/10.1107/S2059798318006691

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