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Figure 3
Magnified view of the internal cavities of the M20-open ecDHFR crystal. (a) 0.1 and (b) 750 MPa structures showing cavities near Leu54. The cavity surrounded by Val40, Met42 and Leu54 disappeared at 750 MPa. (c) 0.1 and (d) 750 MPa structures show a water molecule penetrating into a hydrophobic cavity above Tyr151. Cavities were drawn with the surface-cavity mode of PyMOL using a solvent radius of 1.2 Å. NADP+ and FOL are treated as components of the protein molecule, and water molecules are ignored. The electron density of the water is also drawn at 1.5σ. The 0.1 MPa structure is drawn using the B chain.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
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