Schematics showing the dependence of the cooling response of the unit-cell components on cryosolvent contraction for (a) tetragonal thermolysin and (b) orthorhombic trypsin. Cell and protein contractions were calculated as described in Fig. 1. The channel contraction was calculated according to Δchan = (Δcell − νprotΔprot)/(1 − Δprot). The lines shown are linear fits to the data over most of the range.