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Figure 4
Comparison of different CoV fusion cores reveals differences and similarities in the interactions between their HR1 and HR2 motifs. Cartoon representations illustrating the side-chain electrostatic and polar interactions (a) and main-chain polar interactions (b, c) between HR1 and HR2 in HCoV-229E, HCoV-NL63 (PDB entry 2ieq), SARS (PDB entry 1wyy) and MERS (PDB entry 4njl). Interactions between HR1 residues and the main-chain atoms of HR2 are only seen in the N-terminal (c) and C-terminal (b) extended regions of HR2. The HR1 motifs are depicted as white ribbons and the HR2 motifs as green ribbons. For clarity, only two HR1 motifs of the 3HR1 core are shown. The HR1 and the HR2 residues that are involved in interactions are illustrated as stick models, with black dashed lines representing hydrogen bonds and/or salt bridges. The residues are colour-coded as follows: HR1, whitish grey; HR2, teal (HCoV-229E), hot pink (HCoV-NL63), gold (MERS) and slate (SARS). Interactions that are conserved across different HCoVs are shown as yellow stick models. All polar interactions of HCoV-229E are clearly labelled, whereas only conserved interactions are labelled for the other HCoVs. The labels of HR1 residues are differentiated from those of HR2 residues by a prime after the residue number.

Journal logoSTRUCTURAL
ISSN: 2059-7983
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